Abstract Objective Hypertriglyceridemia (HTG) is one of the Cutting Discs common causes of acute pancreatitis (AP).Hyperlipidemic acute pancreatitis (HTG-AP) is associated with higher mortality owing to its tendency for greater severity and rapid progression.The purpose of this study was to explore the mechanism of involvement of tumor necrosis factor receptor-related factor 6 (TRAF6) in pyroptosis during HTG-AP.Methods The HTG environment was simulated with palmitic acid treatment in vitro and a high-fat diet in vivo.Cerulein was used to establish the HTG-AP model, followed by genetic and pharmacological inhibition of TRAF6.
Pyroptosis activation, inflammatory reaction, and the interaction between TRAF6 and pyroptosis in HTG-AP were assessed.Results HTG was found to aggravate the development of pancreatitis, accompanied by increased pyroptosis and enhanced inflammatory response in HTG-AP models.Mechanistically, TRAF6 downregulation decreased the activation of pyroptosis in cerulein-induced HTG-AP.Conclusion Collectively, inhibition Kids Bamboo Toothbrush of TRAF6 improved HTG-AP and the associated inflammation by alleviating pyroptosis.